The Democratic Republic of Congo kicked off Group A of their third-round World Cup qualifying campaign with a 4-0 win over Libya.
Hull striker Dieumerci Mbokani opened the scoring on six minutes before Jonathan Bolingi slotted into the bottom corner in first-half stoppage time to give the hosts a 2-0 lead at the break.
Mbokani doubled his tally 11 minutes after the interval before Ndombe Mubele also got his name on the scoresheet to seal an emphatic victory.
The Ivory Coast top Group C after coming from behind to win 3-1 at home to Mali in their third-round opener.
Sambou Yatabare gave the visitors the lead after 18 minutes but the hosts hit back with three goals in eight first-half minutes before the break turned the match on its head.
Goals from Aston Villa's record signing Jonathan Kodjia and Gervinho, either side of a Salif Coulibaly own goal, were enough to secure all three points for the Ivory Coast.
Tournament hosts Gabon shared the spoils following a goalless draw with Morocco.
Despite Borussia Dortmund striker Pierre-Emerick Aubameyang leading the line, the hosts were frustrated by the stubborn Moroccan defence as the teams earned a point apiece.
Senegal opened up their campaign in Group D with a 2-0 win against Cape Verde at the Stade Leopold Sedar Senghor.
Lazio forward Balde Keita got on the scoresheet in the 24th minute to set the hosts on their way before Moussa Sow doubled their lead four minutes after coming on as a substitute, flashing the ball into the roof of the net to leave Cape Verde goalkeeper Vozinha with no chance.
World Cup hosts of 2010 South Africa were hit by a stoppage-time equaliser as they were held to a 1-1 draw with Burkina Faso.