England's training squad will gather in Brighton on Sunday for a three-day camp to begin preparing for the Autumn International Rugby series against South Africa, Fiji, Argentina and Australia.
The final group who will seek to preserve Eddie Jones' 100 per cent record since becoming head coach will be named on October 26.
"With a number of players missing through injury it's a good opportunity for others to put their hands up and show us what they're made of," the former Wallabies mentor said on Friday.
"I think it's a good situation to be in. Injuries allow us to strengthen the depth of our squad and develop robustness.
"Ideally, by the Rugby World Cup in 2019 we're looking to have three players in every position who are interchangeable.
"At the moment we have seven of our most influential players not playing regularly for their clubs but that should be no excuse. England have not beaten South Africa since 2006 and this needs to change."
Two days after appointing World Cup winner Richard Hill as team manager, Jones has expanded his management team further with the addition of Rory Teague as skills coach on a part-time basis.
"Rory will primarily be working with the players on their individual skills. This is a temporary appointment and another good opportunity for an English coach to gain experience and develop their coaching at the highest level," Jones said.